The American Society of Dermatopathology

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Interactive Case Study - August 2020

80-year-old with painful chest nodule

Tiffany Y. Chen, MD; Leigh A. Compton, MD, PhD

Question 1:

An 80-year-old man presents with a painful firm nodule on the left upper chest.

Figure 1.

Figure 2.

Figure 3. Keratin

Figure 4. P63

Figure 5. CD45

Figure 6. CD68

Figure 7. EBER

Based on the histologic and immunohistochemical findings below which of the following is the best diagnosis?