The American Society of Dermatopathology

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Interactive Case Study - April 2014

Multiple skeletal fractures and asymptomatic foot nodule (with zoomable virtual slide)

Genevieve L. Egnatios, MD; Tammie Ferringer, MD; R. Patrick Dorion, MD

Question 1:

A 58-year-old male with a history of multiple pathologic skeletal fractures presented with an asymptomatic approximately 1.5 cm nodule on the plantar aspect of his left foot. He had a remote history of injury to the area. An excisional biopsy was performed (Figures 1-5).

Click this image to view the zoomable slide. 

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Which of the following is the best diagnosis?