The American Society of Dermatopathology

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Interactive Case Study - October 2014

Painful mucocutaneous eruption in a middle-aged man

John R. Griffin, MD; Jacqueline M. Junkins-Hopkins, MD

Question 1:

Clinical history: A 49-year-old man was evaluated for diffuse oral mucositis and polymorphic cutaneous eruption. Biopsy from a skin lesion is shown in Figures 1 and 2.

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Figure 1.


Figure 2.

Which of the following is the most likely explanation for these findings?