The American Society of Dermatopathology

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Interactive Case Study - December 2015

Asymptomatic penile ulcer

Emily M Erstine, MD; Ivanka Kovalyshyn, DO

Question 1:

A 20-year-old man presented with a three-week history of an asymptomatic 8-mm ulcerated pink papule on the glans penis.  A biopsy shows the following histopathology on H&E (Figures 1-3) and immunohistochemical staining (Figure 4).

Click image to view the virtual slide

Figure 1. H&E, 4x

Figure 2. H&E, 10x

Figure 3. H&E, 20x

Figure 4. 

Which of the following is the best diagnosis?