The American Society of Dermatopathology

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Interactive Case Study - November 2016

A 34-year-old female with a slowly enlarging yellow plaque on her left lower abdomen

Vasantha L. Gali, MD; Usama A. Yassi, MD; Ali D. Jassim, MD

Question 1:

A 34-year-old female presented with a slowly enlarging 3 x 4 cm ill-defined, cobbled, yellow plaque on her left lower abdomen. It was present since her early childhood. There was patchy hyperpigmentation within the plaque. A punch biopsy was performed. The main clinical differential diagnoses were connective tissue nevus, dermatofibrosarcoma protuberans versus other.

Click this image to view the virtual slide.

Figure 1. Punch biopsy skin 2x

Figure 2. Punch biopsy skin 10x

Figure 3. Punch biopsy skin 20x

Figure 4. Punch biopsy skin 60x

Figure 5. Punch biopsy skin Factor XIIIa

Figure 6. Punch biopsy skin Factor CD34

Figure 7. Punch biopsy skin Factor S100

What is the most likely diagnosis?