The American Society of Dermatopathology

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Interactive Case Study - February 2018

Enlarging vulvar growth in a 51-year-old female

Amy L. Bischoff, BS; Soon Bahrami, MD

Question 1:

A 51-year-old female presented with an enlarging vulvar growth. Biopsy was performed and the histopathology is shown below (Figures 1-8).

Click the image to view the virtual slide 

Figure 1: 20x

Figure 2: 100x

Figure 3: 200x

Figure 4: 400x

Figure 5: S-100, 200x

Figure 6: Desmin, 100x

Figure 7: HMB45, 100x

Figure 8: Smooth Muscle Actin, 100x

Which of the following is the best diagnosis?