My ASDP
+
Sign In
My Profile
My Education
Member Directory
Bylaws
Reports to Membership
Sign Out
Education
+
My Education
Case Study of the Month
Journal of Cutaneous Pathology
Dermpath Appropriate Use Criteria
MOC/CC Programs
Quality Assurance Programs
Essentials of Dermatopathology Course
Annual Meeting Abstracts
ASDP Educational Videos
Meetings & Events
+
Annual Meeting
24th Sister Society Meeting
USCAP-ASDP Companion Meeting
Events Calendar
Physicians in Training
+
Dermatopathology Fellowships
Mentorship Awards
Physician in Training Award
Videos
About ASDP
+
Call for Volunteers
COVID-19 Resources
Leadership
Mission & Vision Statements
Why Join ASDP
Support ASDP
Contact ASDP
Corporate Partners
News for Dermatopathologists
Founders' & Nickel Awards Nomination Instructions
Founders' Award
Walter R. Nickel Award
Future of Dermatopathology Videos
History
Privacy Policy
Procedures for Requesting Removal of Infringing Material
Terms of Use
Data Protection
CASL FAQ
Join
+
Search for:
The American Society of Dermatopathology
Home
Education
Case Study of the Month
View case study archive
Interactive Case Study - March 2018
Wrist nodule on a 74-year-old man
Benjamin L. Mazer, MD, MBA; Jennifer McNiff, MD
Question 1:
A 74-year-old man with a history of rheumatoid arthritis presents with a nodule on his wrist. A biopsy shows the following H&E histopathology (figures 1-3). Special stains and immunohistochemistry reveal the lesion is diffusely positive for CD68 (figure 4) and negative for factor XIIIa (figure 5) and CD34. GMS stain is negative for organisms (figure 6). CD1a (MTB1 clone) immunostain is negative in the spindled cells and does not highlight organisms.
Click this image to view the virtual slide.
Figure 1.
Figure 2.
Figure 3.
Figure 4.
Figure 5.
Figure 6.
What is the next best stain to perform?
A.
Brown-Hopps
B.
S100
C.
Vimentin
D.
Fite
E.
STAT6