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The American Society of Dermatopathology
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Case Study of the Month
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Interactive Case Study - February 2019
An 80-year-old male with a mass on the upper lip
Ashley Craddock, BA; Mark Mochel, MD
Question 1:
An 80-year-old man presented with a 5-cm mass on his left upper lip that had been growing for more than 5 years. Pathologic examination of an excisional biopsy revealed the following:
Click this image to view the virtual slide
Figure I: Whole slide image of a representative section.
Figure II: H&E, 40x (A), 100x (B and C)
Figure III: H&E, 20x magnification
Figure IV: Immunohistochemical stains for cytokeratin-AE1/AE3 (A) and Melan-A (B), 40x magnification, same focus as Figure III
Figure V: H&E, 100x, central zone seen in Figure III
Figure VI: H&E (A) and immunohistochemical slides for p63 (B) and SOX10 (C), 200x magnification, same focus as Figure V
Which of the following is the best diagnosis?
A.
Basal cell carcinoma with melanocytic hyperplasia
B.
Malignant melanoma and basal cell carcinoma (collision/combination tumor)
C.
Malignant melanoma and squamous cell carcinoma (collision/combination tumor)
D.
Melanocytic matricoma
E.
Squamous cell carcinoma and basal cell carcinoma (collision/combination tumor)