The American Society of Dermatopathology

Hermann Pinkus Basic Science Course

Translational Science in Dermatopathology: For Dermatopathologists by Dermatopathologists

Tuesday, November 10
8:00 a.m. - 11:15 a.m. Central Time

Course Director
Michael T. Tetzlaff, MD, PhD
University of California, San Francisco

2.75 AMA PRA Category 1 Credits™

Over the past several years, many fundamental studies in the area of translational dermatopathology have been completed by practicing dermatopathologists. The resulting findings offer critical insights that directly impact daily dermatopathology practice and advance our understanding of how molecular genetic alterations drive the formation of melanocytic and adnexal tumors, molecular impetuses in cutaneous autoimmune disease, and molecular and immunological biomarkers predictive of response and resistance to various systemic therapeutic therapies. Furthermore, as dermatopathologists increasingly rely on digital pathology, the impact of artificial intelligence will continue to further shape daily dermatopathologic practice. This course will provide a practical presentation of a broad array of basic and translational research from the perspective of practicing dermatopathologists for practicing dermatopathologists.

Faculty and Course Outline:

8:00 a.m. - 8:05 a.m.

Michael T. Tetzlaff, MD, PhD
University of California, San Francisco
8:05 a.m.  8:25 a.m.

Molecular Genetic Alterations in Cutaneous Adnexal Tumors
Thomas Brenn, MD, PhD
University of Calgary
8:25 a.m.  8:45 a.m.

Molecular Genetic Alteration in Sebaceous Carcinoma
Jeffrey P. North, MD
University of California, San Francisco
8:45 a.m. - 9:05 a.m.

Molecular Genetics and Immunobiology of Merkel Cell Carcinoma
Paul W. Harms, MD, PhD
Michigan Medicine
9:05 a.m. - 9:25 a.m.

Molecular Genetics and Immunobiology of Connective Tissue Disease
May P. Chan, MD
University of Michigan
9:25 a.m. - 9:45 a.m.

Multiplex Immunohistochemical Studies Identifying Prognostic and
Predictive Biomarkers in Cutaneous Malignancies

Janis M. Taube, MD
Johns Hopkins Uiversity
9:45 a.m. - 10:05 a.m.
Molecular Genetics of Melanocytic Neoplasms
Iwei Yeh, MD, PhD
University of California, San Francisco
10:05 a.m. - 10:25 a.m. Break
10:25 a.m.  10:45 a.m.

Artificial Intelligence in Dermatopathology
Klaus J. Busam, MD
Memorial Sloan Kettering Cancer Center
10:45 a.m. - 11:15 a.m. Q & A and Closing Remarks

Learning Objectives
Upon completion of this course, participants should be able to:

  • Utilize and interpret translational research methods used by other dermatopathologists to increase diagnostic accuracy of melanocytic and adnexal tumors, and improve patient outcomes.
  • Demonstrate greater understanding of relevant molecular genetic drivers of neoplastic skin adnexal tumors, cutaneous melanoma and Merkel cell carcinoma.
  • Identify and describe application of multiplex immunofluorescence studies to identify prognostic/predictive biomarkers in cutaneous malignancies.
  • Describe molecular genetics/immune biology of connective tissue disease.
  • Evaluate pros and cons of application of artificial intelligence in dermatopathology and its impact of diagnostic accuracy and patient outcomes.

Previous Hermann Pinkus Memorial Basic Science Course Directors

In 2010 the format of the Hermann Pinkus Memorial Lecture was changed to encompass a wider range of scientific topics that relate to the field of dermatopathology.

2019 Julia S. Lehman, MD
2018 Jon A. Reed, MD
2017 Melissa P. Piliang, MD
2016 Melissa Pulitzer, MD
2015 Beth S. Ruben, MD
2014 Tammie C. Ferringer, MD
2013 Ronald P. Rapini, MD
2012 Steven D. Billings, MD
2011 Klaus J. Busam, MD
2010 Lawrence E. Gibson, MD
2009 Lisa A. Beck, MD
2008 Norma J. Nowak, PhD
2007 David Fisher, MD, PhD
2006 Sharon Weiss, MD
2005 Boris C. Bastian, MD
2004 Michael W. Piepkorn, MD
2003 A. Razzaque Ahmed, MD
2002 Philip E. LeBoit, MD
2001 Robert C. Gallo, MD
2000 Elaine Fuchs, PhD
1999 Thomas A. Waldmann, MD
1998 David T. Woodley, MD
1997 Karen A. Holbrook, PhD
1996 Judah Folkman, MD
1995 Margaret Kripke, MD
1993 Douglas R. Lowy, MD
1992 Walter R. Gammon, MD
1991 Stephen I. Katz, MD, PhD
1990 Lance A. Liotta, MD, PhD
1989 John R. Stanley, MD
1988 Jouni J. Uitto, MD, PhD
1987 Clive Taylor, MD, PhD
1986 Tung-Tien Sun, PhD